General Information

  • ID:  hor005256
  • Uniprot ID:  P83226
  • Protein name:  Natriuretic peptide TNP-a
  • Gene name:  NA
  • Organism:  Oxyuranus scutellatus canni (Papuan taipan)
  • Family:  natriuretic peptide family
  • Source:  Animal
  • Expression:  Expressed by the venom gland.
  • Disease:  NA
  • Comments:  Does not activate natriuretic peptide receptor-A (NPR1).
  • Taxonomy:  Oxyuranus scutellatus (species), Oxyuranus (genus), Acanthophiinae (subfamily), Elapidae (family), Colubroidea (superfamily), Serpentes (infraorder), Toxicofera, Episquamata, Unidentata, Bifurcata, Squamata (order), Lepidosauria (class), Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0090729 toxin activity
  • GO BP:  GO:0007165 signal transduction; GO:0008217 regulation of blood pressure; GO:0035821 modulation of process of another organism; GO:0042311 vasodilation; GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SDSKIGDGCFGLPLDHIGSVSGLGCNRPVQNRPKK
  • Length:  35(1-35)
  • Propeptide:  SDSKIGDGCFGLPLDHIGSVSGLGCNRPVQNRPKK
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Exhibits vasoactive and hypotensive activity
  • Mechanism:  Negative results: does not activate natriuretic peptide receptor-A (NPR1).
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  45925
  • Structure ID:  AF-P83226-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P83226-F1.pdbhor005256_AF2.pdbhor005256_ESM.pdb

Physical Information

Mass: 425979 Formula: C155H255N49O49S2
Absent amino acids: AEMTWY Common amino acids: G
pI: 8.82 Basic residues: 6
Polar residues: 14 Hydrophobic residues: 8
Hydrophobicity: -53.43 Boman Index: -6587
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 72.29
Instability Index: 4735.71 Extinction Coefficient cystines: 125
Absorbance 280nm: 3.68

Literature

  • PubMed ID:  15652496
  • Title:  Novel natriuretic peptides from the venom of the inland taipan (Oxyuranus microlepidotus): isolation, chemical and biological characterisation.